Redox mechanism of anticancer drug idarubicin and in-situ evaluation of interaction with DNA using an electrochemical biosensor

Kara H. E.

BIOELECTROCHEMISTRY, cilt.99, ss.17-23, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 99
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.bioelechem.2014.06.002
  • Dergi Adı: BIOELECTROCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.17-23
  • Anahtar Kelimeler: Idarubicin, Electrochemical biosensor, Drug-DNA interaction, Oxidation, Voltammetry, LIQUID-CHROMATOGRAPHY, GLASSY-CARBON, ANTHRACYCLINES, METABOLITES, PLASMA, SERUM
  • Gazi Üniversitesi Adresli: Evet

Özet

Idarubicin (IDA), 4-demethoxydaunorubicin, is an anthracycline derivative and widely used treatment of leukemia. The electrochemical behavior of IDA was examined at a glassy carbon electrode (GCE) in different aqueous supporting electrolyte using cyclic voltammetty (CV) and differential pulse voltammetry (DPV). The oxidation process of IDA was found to be pH dependent and irreversible proceeding with a transfer of 1 proton and 1 electron under the diffusion controlled mechanism. The electroactive center is the hydroxyl group on the aromatic ring which produces a final quinonic product. The diffusion coefficient of IDA was calculated to be D-IDA = 7.47 x 10(-6) cm(2) s(-1) in pH = 4.3 0.1 M acetate buffer.