Fluorescent and Biocompatible Nitrogen and Sulfur Co-Doped Carbon Nanodot as an Ocular Fundus Angiography Imaging Agent

Ilhan H., Erdem B., Ozkasapoglu S., Yayla M., Bas O., ÇELİKKAN H.

Journal of Fluorescence, cilt.33, sa.5, ss.1917-1925, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10895-023-03200-8
  • Dergi Adı: Journal of Fluorescence
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chimica, Compendex, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1917-1925
  • Anahtar Kelimeler: Carbon nanodots, Fluorescence imaging, Fundus angiography
  • Gazi Üniversitesi Adresli: Evet

Özet

The florescence characteristics and the toxicities of carbon nanodots (CDs) are directly related to their elemental compositions. Fluorescent and non-toxic agent for imaging of biological systems was aimed. Sulfur and nitrogen co-doped CDs (S/N-CDs) was hydrothermally produced in an average size of 8 nm. S/N-CDs showed blue fluorescence under UV-light with an excitation wavelength of 365 nm. After 24 h, S/N-CDs was non-cytotoxic in HUVEC and L929 cells. S/N-CDs have a great potential to act as an alternative material for commercial fluorescent materials with its 85.5% of quantum yield. S/N-CDs was approved in vitro as an imaging agent for an ocular fundus angiography of rats.