Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?

Tecer D., Sunar I., Ozdemirel A. E., Tural R., Kucuksahin O., SEPİCİ DİNÇEL A., ...Daha Fazla

ADVANCES IN RHEUMATOLOGY, cilt.59, sa.1, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1186/s42358-019-0096-2
  • Dergi Adı: ADVANCES IN RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Atherogenic indexes, Atherosclerosis, Ca-LDL, Carotid intima-media thickness, Psoriatic arthritis, INTIMA-MEDIA THICKNESS, HOMEOSTASIS MODEL ASSESSMENT, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, ENDOTHELIAL-CELLS, RHEUMATOID-ARTHRITIS, LIPOPROTEIN RATIOS, PLASMA, DISEASE, MARKERS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background To investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA). Methods Thirty-ninepatients and 19 age, sex, body mass index matched healthy controls were included. Insulin resistance (IR) was assessed with homeostasis of model assessment-IR (HOMA-IR). Carotid intima-media thickness (CIMT) was measured at both common carotid arteries and mean CIMT was calculated. Results The mean age was 49.50 +/- 11.86 years and 64.1% were females in PsA group. In the PsA group, CIMT and HOMA-IR were significantly higher (p = 0.003, p = 0.043, respectively). AIP, AC, TG/HDL, CRI-1, CRI-2 and ca-LDL levels were similar between groups. In PsA group, CIMT was positively correlated with HOMA-IR, TG/HDL and AIP. Although ca-LDL was positively correlated with serum amyloid A (r = 0.744, p < 0.001), no correlation was detected between ca-LDL and CIMT (r = 0.215, p = 0.195). PsA patients with IR tended to have higher ca-LDL levels than patients without IR, but this difference lacked statistical significance (33.65 +/- 26.94, 28.63 +/- 28.06, respectively, p = 0.237). Conclusions A significant increase in CIMT was seen in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors. CIMT was correlated with HOMA-IR, TG/HDL and AIP.